NIH Policies

Coming soon: The Office of Animal Care and Use website will transition to NIH internal access only. This change better aligns access with the intended audience and is consistent with the 2026 NIH modernized web presence initiative. To learn more about the new web experience, visit https://www.nih.gov/web-modernization(external link).

NIH Policy Manual Chapters:

• Manual 3040-2: Animal Care and Use in the Intramural Program
• Manual 3040-3: Intramural Acquisitions Involving Animal Research Activities
• Manual 3043-1: Introduction of Rodents and Rodent Products
• Manual 3044-1: Nonhuman Primate Quarantine
• Manual 3044-2: Protection of NIH Personnel Who Work With Nonhuman Primates
• Manual 3047: Trans-NIH Animal Facility Security Program
• Manual 3015: Admittance Of Minors To Hazardous Areas
• Manual 1345: Handling and Safeguarding of Controlled Substances for Nonhuman Use
• Manual 1340: NIH Occupational Safety and Health Management Program
• Manual 1165: Agency Agreements
• Manual 1184: Preparation and Clearance of Scientific, Technical, and Public Information Presented by NIH Employees or Produced for Distribution by NIH
• Manual 6307-3: Special Clearance and Other Acquisition Procedures

DDIR Institutional Official Policy Memos:

• Scientific Merit Review for the Use of Nonhuman Primates, 02/14/2023
• Updates to the Nonhuman Primate Users Safety Program, 10/08/2024
  • Nonhuman Primate and Other Research Animal Bite, Scratch, Splash, and Exposure (BSSE) Guidelines, 10/27/2022
• Disposition of Laboratory Animals, 05/09/2023
• NIH Intramural Research Program Animal Study Proposal (ASP) Template, 04/22/2014
  • NIH IRP Animal Study Proposal Template
  • NIH IRP ASP Template Instructions for Emergency Animal Treatment and Care
• Purchase of Custom Antibodies, 11/07/2022
  • Custom Antibody Vendor List, 04/02/2025
• Reporting Concerns Regarding Animals at NIH
  • Communicating Animal Care and Use Concerns within the NIH Intramural Research Program, 09/23/2022
• Timely Assessment and Resolution of Animal Issues Involving Potential Pain and/or Distress, 09/27/2023

Other NIH Policies:

• DOHS SOP: Visitors to Animal Research Facilities, 05/23/2024
• Research Animal Transport for the NIH Clinical Center, 02/26/2024
• Use of Embryonated Eggs, 09/28/2022 

This page was last updated on Tuesday, July 28, 2026